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 Drug Delivery: Targeted Drug Delivery

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Targeted Drug Delivery in Disease Therapeutics

 

The ability to deliver drugs to specific cells has long been regarded as the next major milestone in drug therapeutics. Targeting drugs to the cellular level is expected to minimize drug side effects, expand their use and improve patient outcomes. More than thirty companies are now working to develop targeted drug delivery methods that pinpoint specific cells. Most of these approaches rely on the use of ligands capable of binding to cell surface receptors preferentially expressed on targeted cells. Other promising technologies include target-cell activation and energy activation of a localized drug. The majority of targeted drug delivery efforts in development have oncology drugs as their focus. While the current generation of targeted drug delivery platforms is designed for adaptability to a range of drugs, the degree of tailoring required is still somewhat significant. Clinical experience will enable optimized versions of several platforms that will reduce time-to-market.

Publication: February 2008

 
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