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Targeted
Drug Delivery in Disease Therapeutics
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The ability to deliver drugs to specific
cells has long been regarded as the next major milestone in drug
therapeutics. Targeting drugs to the cellular level is expected to
minimize drug side effects, expand their use and improve patient
outcomes. More than thirty companies are now working to develop targeted
drug delivery methods that pinpoint specific cells. Most of these approaches
rely on the use of ligands capable of binding to cell surface receptors
preferentially expressed on targeted cells. Other promising technologies
include target-cell activation and energy activation of a localized
drug. The majority of targeted drug delivery efforts in development have
oncology drugs as their focus. While the current generation of targeted
drug delivery platforms is designed for adaptability to a range of drugs, the
degree of tailoring required is still somewhat significant. Clinical
experience will enable optimized versions of several platforms that will
reduce time-to-market.
Publication: February 2008 |
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